Gene expression responses to anti-tuberculous drugs in a whole blood model

Gene expression responses to anti-tuberculous drugs in a whole blood model

Abstract Background There is a need for better tools to evaluate new or repurposed TB drugs. The whole blood bactericidal activity (WBA) assay has been advocated for this purpose. We investigated whether transcriptional responses in the WBA assay resemble TB responses in vivo, and whether the approa...

Full description

Bibliographic Details
Main Authors: Philip Kam Weng Kwan, Wenwei Lin, Ahmad Nazri Mohamed Naim, Balamurugan Periaswamy, Paola Florez De Sessions, Martin L. Hibberd, Nicholas I. Paton
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Microbiology
Subjects:
Tuberculosis
Gene expression
Transcriptome
Mechanism of action
Anti-tuberculosis drugs
Whole blood assay
Online Access:http://link.springer.com/article/10.1186/s12866-020-01766-y

Internet

http://link.springer.com/article/10.1186/s12866-020-01766-y

Similar Items