Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson’s Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology

Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson’s Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology

Accumulation of α-synuclein (α-syn) into Lewy bodies (LBs) and mitochondrial abnormalities are the two cardinal pathobiological features of Parkinson’s disease (PD), which are associated with the loss of dopaminergic neurons. Although α-syn accumulates in many different cellular and mouse models, th...

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Bibliographic Details
Main Authors: Xiaojun Diao, Fei Wang, Andrea Becerra-Calixto, Claudio Soto, Abhisek Mukherjee
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
Parkinson’s disease
iPSC
dopaminergic neurons
α-synuclein aggregates
Lewy bodies
mitochondria
Online Access:https://www.mdpi.com/2073-4409/10/9/2402

Internet

https://www.mdpi.com/2073-4409/10/9/2402

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