Osthole Attenuates Macrophage Activation in Experimental Asthma by Inhibitingthe NF-ĸB/MIF Signaling Pathway

Osthole Attenuates Macrophage Activation in Experimental Asthma by Inhibitingthe NF-ĸB/MIF Signaling Pathway

Inhibition of activated macrophages is an alternative therapeutic strategy for asthma. We investigated whether a coumarin compound, osthole, isolated from Cnidiummonnieri (L.) Cuss, alleviated macrophage activation in vivo and in vitro. Osthole could reduce expression of a marker of activated macrop...

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Bibliographic Details
Main Authors: Ruyi Li, Peng Song, Guofang Tang, Jianghong Wei, Lizong Rao, Libing Ma, Ming Jiang, Jianwei Huang, Qing Xu, Jingjie Wu, Qian Lv, Dong Yao, Bo Xiao, Haiming Huang, Liping Lei, Juntao Feng, Biwen Mo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
osthole
macrophages
asthma
NF-ĸB
MIF 46
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.572463/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.572463/full

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