Pimaradienoic Acid Inhibits Carrageenan-Induced Inflammatory Leukocyte Recruitment and Edema in Mice: Inhibition of Oxidative Stress, Nitric Oxide and Cytokine Production.

Pimaradienoic Acid Inhibits Carrageenan-Induced Inflammatory Leukocyte Recruitment and Edema in Mice: Inhibition of Oxidative Stress, Nitric Oxide and Cytokine Production.

Pimaradienoic acid (PA; ent-pimara-8(14),15-dien-19-oic acid) is a pimarane diterpene found in plants such as Vigueira arenaria Baker (Asteraceae) in the Brazilian savannas. Although there is evidence on the analgesic and in vitro inhibition of inflammatory signaling pathways, and paw edema by PA, i...

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Main Authors: Sandra S Mizokami, Miriam S N Hohmann, Larissa Staurengo-Ferrari, Thacyana T Carvalho, Ana C Zarpelon, Maria I Possebon, Anderson R de Souza, Rodrigo C S Veneziani, Nilton S Arakawa, Rubia Casagrande, Waldiceu A Verri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4760730?pdf=render

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http://europepmc.org/articles/PMC4760730?pdf=render

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