ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction

ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction

Abstract Background A disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by activated leukocytes, and fibroblasts in vitro. Whether ADAM15 expression is increased in the lungs of COPD patients is not known. Methods ADAM15 gene expression and/or protein levels were measured in whole lu...

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Bibliographic Details
Main Authors: Xiaoyun Wang, Duo Zhang, Andrew Higham, Sophie Wolosianka, Xiaoyan Gai, Lu Zhou, Hans Petersen, Victor Pinto-Plata, Miguel Divo, Edwin K. Silverman, Bartolome Celli, Dave Singh, Yongchang Sun, Caroline A. Owen
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Respiratory Research
Subjects:
COPD
Cigarette smoke
Macrophage; CD8+ T cell
Epithelial cell
Forced expiratory volume in 1 s
Airflow obstruction
Online Access:http://link.springer.com/article/10.1186/s12931-020-01446-5

Internet

http://link.springer.com/article/10.1186/s12931-020-01446-5

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