Achillin Increases Chemosensitivity to Paclitaxel, Overcoming Resistance and Enhancing Apoptosis in Human Hepatocellular Carcinoma Cell Line Resistant to Paclitaxel (Hep3B/PTX)

Achillin Increases Chemosensitivity to Paclitaxel, Overcoming Resistance and Enhancing Apoptosis in Human Hepatocellular Carcinoma Cell Line Resistant to Paclitaxel (Hep3B/PTX)

Multidrug resistance (MDR) has become a major obstacle in the treatment of cancer, and is associated with mechanisms such as increased drug outflow, reduction of apoptosis, and/or altered drug metabolism. These problems can be mitigated by the coadministration of agents known as chemosensitizers, as...

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Bibliographic Details
Main Authors: Jessica Nayelli Sanchez-Carranza, Leticia González-Maya, Rodrigo Said Razo-Hernández, Enrique Salas-Vidal, Ninfa Yaret Nolasco-Quintana, Aldo F. Clemente-Soto, Lucero García-Arizmendi, Mariana Sánchez-Ramos, Silvia Marquina, Laura Alvarez
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pharmaceutics
Subjects:
achillin
chemosensitization
multidrug resistance
paclitaxel
hepatocellular carcinoma
p-glycoprotein
Online Access:https://www.mdpi.com/1999-4923/11/10/512

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https://www.mdpi.com/1999-4923/11/10/512

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