Integration of SNP and mRNA arrays with microRNA profiling reveals that MiR-370 is upregulated and targets NF1 in acute myeloid leukemia.

Integration of SNP and mRNA arrays with microRNA profiling reveals that MiR-370 is upregulated and targets NF1 in acute myeloid leukemia.

BACKGROUND: Deregulated miRNA expression plays a crucial role in carcinogenesis. Recent studies show different mechanisms leading to miRNA deregulation in cancer; however, alterations affecting miRNAs by DNA copy number variations (CNV) remain poorly studied. RESULTS: Our integrative analysis includ...

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Bibliographic Details
Main Authors: Laura García-Ortí, Ion Cristóbal, Cristina Cirauqui, Elisabet Guruceaga, Nerea Marcotegui, María J Calasanz, Remedios Castello-Cros, María D Odero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3471844?pdf=render

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http://europepmc.org/articles/PMC3471844?pdf=render

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