A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration

A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration

Abstract Cellular senescence is a major hurdle for primary cell-based tissue engineering and regenerative medicine. Telomere erosion, oxidative stress, the expression of oncogenes and the loss of tumor suppressor genes all may account for the cellular senescence process with the involvement of vario...

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Bibliographic Details
Main Authors: Yiming Wang, Song Chen, Zuoqin Yan, Ming Pei
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cell & Bioscience
Subjects:
Cell senescence
Decellularized cell-deposited extracellular matrix
Differentiation
Immortalization
Proliferation
SV40
Online Access:http://link.springer.com/article/10.1186/s13578-018-0264-9

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http://link.springer.com/article/10.1186/s13578-018-0264-9

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