Oxidation-Specific Epitopes (OSEs) Dominate the B Cell Response in Murine Polymicrobial Sepsis

Oxidation-Specific Epitopes (OSEs) Dominate the B Cell Response in Murine Polymicrobial Sepsis

In murine abdominal sepsis by colon ascendens stent peritonitis (CASP), a strong increase in serum IgM and IgG antibodies was observed, which reached maximum values 14 days following sepsis induction. The specificity of this antibody response was studied in serum and at the single cell level using a...

Full description

Bibliographic Details
Main Authors: Oliver Nicolai, Christian Pötschke, Dina Raafat, Julia van der Linde, Sandra Quosdorf, Anna Laqua, Claus-Dieter Heidecke, Claudia Berek, Murthy N. Darisipudi, Christoph J. Binder, Barbara M. Bröker
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
CASP
polymicrobial sepsis
B cell response
polyreactive antibodies
oxidation-specific epitopes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01570/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01570/full

Similar Items