Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response

Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response

We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production),...

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Bibliographic Details
Main Authors: V. A. Sergeeva, E. S. Ershova, N. N. Veiko, E. M. Malinovskaya, A. A. Kalyanov, L. V. Kameneva, S. V. Stukalov, O. A. Dolgikh, M. S. Konkova, A. V. Ermakov, V. P. Veiko, V. L. Izhevskaya, S. I. Kutsev, S. V. Kostyuk
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2017/9515809

Internet

http://dx.doi.org/10.1155/2017/9515809

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