Biofilm-Induced Type 2 Innate Immunity in a Cystic Fibrosis Model of Pseudomonas aeruginosa

Biofilm-Induced Type 2 Innate Immunity in a Cystic Fibrosis Model of Pseudomonas aeruginosa

Biofilm-producing strains of Pseudomonas aeruginosa are a major cause of morbidity and mortality in cystic fibrosis (CF) patients. In these patients, increased levels of IL-17 as well as of IL-5 and IL-13 along with arginase (Arg)-positive macrophages have been observed in bronchoalveolar lavage flu...

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Bibliographic Details
Main Authors: Kenny Bielen, Bart ‘S Jongers, Jan Boddaert, Tom K. Raju, Christine Lammens, Surbhi Malhotra-Kumar, Philippe G. Jorens, Herman Goossens, Samir Kumar-Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
P. aeruginosa pneumonia
chronic pneumonia
animal model
agar beads
M2 macrophage
eosinophil
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00274/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00274/full

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