Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity.
DNA ligase IV (Dnl4 in budding yeast) is a specialized ligase used in non-homologous end joining (NHEJ) of DNA double-strand breaks (DSBs). Although point and truncation mutations arise in the human ligase IV syndrome, the roles of Dnl4 in DSB repair have mainly been examined using gene deletions. H...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-06-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3694833?pdf=render |