Differential expression and function of PDE8 and PDE4 in effector T cells: Implications for PDE8 as a drug target in inflammation.

Differential expression and function of PDE8 and PDE4 in effector T cells: Implications for PDE8 as a drug target in inflammation.

Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs). We have previously shown that PDE8A, a PDE isoform with 40-100-...

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Bibliographic Details
Main Authors: Amanda G. Vang, Hongli Dong, Rebecca K. Nguyen, Chaitali Basole, William Housley, Linda Guernsey, Alexander J Adami, Roger Thrall, Robert Bennett Clark, Paul Mark Epstein, Stefan Brocke
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Pharmacology
Subjects:
T cell
Adhesion
cAMP
cyclic nucleotide phosphodiesterases (PDEs)
PDE8A
PDE8 inhibitor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00259/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00259/full

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