Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice

Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice

Fluorescent calcium indicators are often used to investigate neural dynamics, but the relationship between fluorescence and action potentials (APs) remains unclear. Most APs can be detected when the soma almost fills the microscope’s field of view, but calcium indicators are used to image population...

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Bibliographic Details
Main Authors: Lawrence Huang, Peter Ledochowitsch, Ulf Knoblich, Jérôme Lecoq, Gabe J Murphy, R Clay Reid, Saskia EJ de Vries, Christof Koch, Hongkui Zeng, Michael A Buice, Jack Waters, Lu Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
calcium imaging
genetically encoded calcium indicator
action potential
excitatory neurons
cell-attached recording
calibration
Online Access:https://elifesciences.org/articles/51675

Internet

https://elifesciences.org/articles/51675

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