Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation

Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation

Proteolysis targeting chimeras (PROTAC) represents a new type of small molecule induced protein degradation technology that has emerged in recent years. PROTAC uses bifunctional small molecules to induce ubiquitination of target proteins and utilizes intracellular proteasomes for chemical knockdown....

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Bibliographic Details
Main Authors: Ming He, Wenxing Lv, Yu Rao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PROTAC
protein degradation
E3 ubiquitin ligase
proteasome
small molecule inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.685106/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.685106/full

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