[18F]PBR146 and [18F]DPA-714 in vivo Imaging of Neuroinflammation in Chronic Hepatic Encephalopathy Rats

[18F]PBR146 and [18F]DPA-714 in vivo Imaging of Neuroinflammation in Chronic Hepatic Encephalopathy Rats

Neuroinflammation is an important pathogenesis of hepatic encephalopathy (HE). The upregulation of translocator protein (TSPO) during neuroinflammation provides an imaging molecular target to evaluate the severity of neuroinflammation in chronic HE rats. [18F]DPA-714 and [18F]PBR146 targeting TSPO a...

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Bibliographic Details
Main Authors: Xiang Kong, Song Luo, Yun Fei Wang, Gui Fen Yang, Guang Ming Lu, Long Jiang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Neuroscience
Subjects:
hepatic encephalopathy
positron emission tomography
neuroinflammation
translocator protein
cognition
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.678144/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.678144/full

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