TCF7L2 regulates pancreatic β-cell function through PI3K/AKT signal pathway

TCF7L2 regulates pancreatic β-cell function through PI3K/AKT signal pathway

Abstract Background Transcription factor 7-like 2 (TCF7L2), which previously known as TCF-4, is a major form of transcription factor involved in the downstream WNT signaling and exhibits the strongest association to diabetes susceptibility. Although we still do not know mechanistically how TCF7L2 ex...

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Bibliographic Details
Main Authors: Hui-Hui Wu, Yan-Liang Li, Nai-Jia Liu, Zhen Yang, Xiao-Ming Tao, Yan-Ping Du, Xuan-Chun Wang, Bin Lu, Zhao-Yun Zhang, Ren-Ming Hu, Jie Wen
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Diabetology & Metabolic Syndrome
Subjects:
TCF7L2
PI3K/AKT signal pathway
Insulin secretion
PIK3R1
Online Access:http://link.springer.com/article/10.1186/s13098-019-0449-3

Internet

http://link.springer.com/article/10.1186/s13098-019-0449-3

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