Functional Characterization of Three Concomitant MtDNA LHON Mutations Shows No Synergistic Effect on Mitochondrial Activity.

Functional Characterization of Three Concomitant MtDNA LHON Mutations Shows No Synergistic Effect on Mitochondrial Activity.

The presence of more than one non-severe pathogenic mutation in the same mitochondrial DNA (mtDNA) molecule is very rare. Moreover, it is unclear whether their co-occurrence results in an additive impact on mitochondrial function relative to single mutation effects. Here we describe the first exampl...

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Bibliographic Details
Main Authors: Alberto Cruz-Bermúdez, Ramiro J Vicente-Blanco, Rosana Hernández-Sierra, Mayte Montero, Javier Alvarez, Mar González Manrique, Alberto Blázquez, Miguel Angel Martín, Carmen Ayuso, Rafael Garesse, Miguel A Fernández-Moreno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4718627?pdf=render

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http://europepmc.org/articles/PMC4718627?pdf=render

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