Streptococcal Endo-β-N-Acetylglucosaminidase Suppresses Antibody-Mediated Inflammation In Vivo

Streptococcal Endo-β-N-Acetylglucosaminidase Suppresses Antibody-Mediated Inflammation In Vivo

Endo-β-N-acetylglucosaminidase (EndoS) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes. Recombinant EndoS hydrolyzes the β-1,4-di-N-acetylchitobiose core of the N-linked complex type glycan on the asparagine 297 of the γ-chains of IgG. Here, we report that EndoS and IgG hydrolyz...

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Bibliographic Details
Main Authors: Kutty Selva Nandakumar, Mattias Collin, Kaisa E. Happonen, Susanna L. Lundström, Allyson M. Croxford, Bingze Xu, Roman A. Zubarev, Merrill J. Rowley, Anna M. Blom, Christian Kjellman, Rikard Holmdahl
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
endoglycosidase
arthritis
rheumatoid
glycosylation
mouse models
complement
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01623/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01623/full

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