Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy

Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy

Summary: Growing evidences are suggesting that extra-long genes in mammals are vulnerable for full-gene length transcription and dysregulation of long genes is a mechanism underlying human genetic disorders. How long-distance transcription is achieved is a fundamental question to be elucidated. In p...

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Bibliographic Details
Main Authors: Motoyasu Hosokawa, Akihide Takeuchi, Jun Tanihata, Kei Iida, Shin'ichi Takeda, Masatoshi Hagiwara
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219300574

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http://www.sciencedirect.com/science/article/pii/S2589004219300574

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