Enhanced production of antifungal lipopeptide iturin A by Bacillus amyloliquefaciens LL3 through metabolic engineering and culture conditions optimization

Enhanced production of antifungal lipopeptide iturin A by Bacillus amyloliquefaciens LL3 through metabolic engineering and culture conditions optimization

Abstract Background Iturins, which belong to antibiotic cyclic lipopeptides mainly produced by Bacillus sp., have the potential for application in biomedicine and biocontrol because of their hemolytic and antifungal properties. Bacillus amyloliquefaciens LL3, isolated previously by our lab, possesse...

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Bibliographic Details
Main Authors: Yulei Dang, Fengjie Zhao, Xiangsheng Liu, Xu Fan, Rui Huang, Weixia Gao, Shufang Wang, Chao Yang
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Microbial Cell Factories
Subjects:
Iturin A
Bacillus amyloliquefaciens
Promoter substitution
Response surface methodology
Pleiotropic regulator
Online Access:http://link.springer.com/article/10.1186/s12934-019-1121-1

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http://link.springer.com/article/10.1186/s12934-019-1121-1

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