The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin.
The tumour suppressor Adenomatous Polyposis Coli (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood. Using demembranated sperm chromatin exposed to meiotic Xenopus egg extract and HeLa cells expressing fluorescently labelled histones, we established tha...
Main Authors: | Dina Dikovskaya, Guennadi Khoudoli, Ian P Newton, Gaganmeet S Chadha, Daniel Klotz, Ashwat Visvanathan, Angus Lamond, Jason R Swedlow, Inke S Näthke |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3374815?pdf=render |
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