Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of β-Catenin Target Genes

Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of β-Catenin Target Genes

Epigenetic mechanisms play a key role in gastrointestinal cancer (GIC) development and progression, and most studies have been focused on aberrant DNA methylation and histone modifying enzymes. However, the histone H3–H4 chaperone ASF1A is an important factor regulating chromatin assembling and gene...

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Bibliographic Details
Main Authors: Xiuming Liang, Xiaotian Yuan, Jingya Yu, Yujiao Wu, Kailin Li, Chao Sun, Shuyan Li, Li Shen, Feng Kong, Jihui Jia, Magnus Björkholm, Dawei Xu
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:EBioMedicine
Subjects:
ASF1A
β-Catenin
Gastrointestinal cancer
Histone modification
ZEB1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417302359

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http://www.sciencedirect.com/science/article/pii/S2352396417302359

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