Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine

Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine

The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized. Here, we examined the regulation of tyrosine hydroxylase (TH) by tyramine and beta-phenylethylamine (β-PEA)...

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Bibliographic Details
Main Authors: Xiaoqun Zhang, Ioannis Mantas, Alexandra Alvarsson, Takashi Yoshitake, Mohammadreza Shariatgorji, Marcela Pereira, Anna Nilsson, Jan Kehr, Per E. Andrén, Mark J. Millan, Karima Chergui, Per Svenningsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
trace amine-associated receptor 1
tyrosine hydroxylase
evoked dopamine release
tyramine
T1AM
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00166/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00166/full

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