Neuroprotective Effects of Proanthocyanidins, Natural Flavonoids Derived From Plants, on Rotenone-Induced Oxidative Stress and Apoptotic Cell Death in Human Neuroblastoma SH-SY5Y Cells

Neuroprotective Effects of Proanthocyanidins, Natural Flavonoids Derived From Plants, on Rotenone-Induced Oxidative Stress and Apoptotic Cell Death in Human Neuroblastoma SH-SY5Y Cells

Proanthocyanidins (PA) are natural flavonoids widely present in many vegetables, fruits, nuts and seeds, and especially in grape seed. In the present study, we examined the neuroprotective effects of PA and the underlying molecular mechanism in rotenone model of Parkinson's disease (PD). We fou...

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Bibliographic Details
Main Authors: Jian Ma, Shan-Shan Gao, Hai-Jie Yang, Mian Wang, Bin-Feng Cheng, Zhi-Wei Feng, Lei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Neuroscience
Subjects:
proanthocyanidin
oxidative stress
apoptosis
p38
JNK
ERK
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00369/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00369/full

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