Sildenafil preserves diastolic relaxation after reduction by L-NAME and increases phosphodiesterase-5 in the intercalated discs of cardiac myocytes and arterioles

Sildenafil preserves diastolic relaxation after reduction by L-NAME and increases phosphodiesterase-5 in the intercalated discs of cardiac myocytes and arterioles

OBJECTIVES: We investigated the influence of sildenafil on cardiac contractility and diastolic relaxation and examined the distribution of phosphodiesterase-5 in the hearts of hypertensive rats that were treated with by NG-nitro-L-arginine methyl ester (L-NAME). METHODS: Male Wistar rats were treate...

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Bibliographic Details
Main Authors: Silvia Elaine Ferreira-Melo, Caroline Demacq, Silvia Lacchini, José Eduardo Krieger, Maria Cláudia Irigoyen, Heitor Moreno
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2011-01-01
Series:Clinics
Subjects:
Hypertension
Phosphodiesterase-5 Inhibitor
Immunohistochemistry
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000700022

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000700022

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