Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction

Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction

Multinucleated giant cells (MGCs) form by fusion of macrophages and are presumed to contribute to the removal of debris from tissues. In a systematic in vitro analysis, we show that IL-4-induced MGCs phagocytosed large and complement-opsonized materials more effectively than their unfused M2 macroph...

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Bibliographic Details
Main Authors: Ronny Milde, Julia Ritter, Glenys A. Tennent, Andrzej Loesch, Fernando O. Martinez, Siamon Gordon, Mark B. Pepys, Admar Verschoor, Laura Helming
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715012541

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http://www.sciencedirect.com/science/article/pii/S2211124715012541

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