A comprehensive analysis of the structure-function relationship in proteins based on local structure similarity.

BACKGROUND:Sequence similarity to characterized proteins provides testable functional hypotheses for less than 50% of the proteins identified by genome sequencing projects. With structural genomics it is believed that structural similarities may give functional hypotheses for many of the remaining p...

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Bibliographic Details
Main Authors: Torgeir R Hvidsten, Astrid Laegreid, Andriy Kryshtafovych, Gunnar Andersson, Krzysztof Fidelis, Jan Komorowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2705683?pdf=render