Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK

Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK

Background/Aims: Thrombin induces the activation of human platelets through protease-activated receptor (PAR) 1 and PAR4, and Rac, a member of the Rho family of small GTPases, is implicated in PAR activation. We previously reported that phosphorylated-heat shock protein 27 (HSP27) is released from t...

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Bibliographic Details
Main Authors: Kodai Uematsu, Yukiko Enomoto, Takashi Onuma, Masanori Tsujimoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Haruhiko Tokuda, Shinji Ogura, Hiroki Iida, Osamu Kozawa, Toru Iwama
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Platelet
Rac
p38 MAP kinase
JNK
Protease-activated receptor
Thrombin receptor-activating peptide
Heat shock protein 27
Phosphorylation
Online Access:https://www.karger.com/Article/FullText/493456

Internet

https://www.karger.com/Article/FullText/493456

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