Interleukin-17A: Potential mediator and therapeutic target in hypertension

Interleukin-17A: Potential mediator and therapeutic target in hypertension

Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by cells of the immune system, predominantly Th17 and γδ lymphocytes. In this paper, we review the role of IL-17A in the pathogenesis of hypertension and in target organ damage. Preclinical studies in mice have shown that systemic admin...

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Bibliographic Details
Main Authors: Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Macarena Orejudo, Laura Marquez-Exposito, Laura Santos-Sanchez, Sandra Rayego-Mateos, Elena Cantero-Navarro, Lucia Tejedor-Santamaria, Vanessa Marchant, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Rafael Selgas, Juan F. Navarro-González, Jose M. Valdivielso, Carolina Lavoz, Marta Ruiz-Ortega
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Nefrología (English Edition)
Subjects:
Hipertensión
IL-17A
Respuesta inmune
Inflamación
Citoquinas
Enfermedad renal crónica
Online Access:http://www.sciencedirect.com/science/article/pii/S2013251421000572

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http://www.sciencedirect.com/science/article/pii/S2013251421000572

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