Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature.

Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature.

Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-γ which triggers their ability to kill the intracellular parasites. Consistent with this, transcriptional a...

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Bibliographic Details
Main Authors: Camila Farias Amorim, Fernanda O Novais, Ba T Nguyen, Mauricio T Nascimento, Jamile Lago, Alexsandro S Lago, Lucas P Carvalho, Daniel P Beiting, Phillip Scott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0009321

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https://doi.org/10.1371/journal.pntd.0009321

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