N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold

N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold

How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N-linked glycans help to prevent retarding intermol...

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Bibliographic Details
Main Authors: Andreas J. W. Hartel, Marius Glogger, Nicola G. Jones, Wasim Abuillan, Christopher Batram, Anne Hermann, Susanne F. Fenz, Motomu Tanaka, Markus Engstler
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12870

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https://doi.org/10.1038/ncomms12870

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