APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection
An et al. determine the presence of variants of the innate immune factor APOL1 in four cohorts of HIV-positive patients. The study suggests that APOL1 might confer carriers of two variant alleles protection from HIV related opportunistic infections, especially fungal infections.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01812-z |
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doaj-831bd8c038714b82bb61a55cbf435f8a2021-03-11T12:03:56ZengNature Publishing GroupCommunications Biology2399-36422021-03-01411810.1038/s42003-021-01812-zAPOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infectionPing An0Efe Sezgin1Gregory D. Kirk2Priya Duggal3Elizabeth Binns-Roemer4George Nelson5Sophie Limou6Mark L. Van Natta7Douglas A. Jabs8Michelle Estrella9Jeffrey B. Kopp10Cheryl A. Winkler11Basic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer ResearchBasic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer ResearchDepartment of Epidemiology, the Johns Hopkins Bloomberg School of Public HealthDepartment of Epidemiology, the Johns Hopkins Bloomberg School of Public HealthBasic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer ResearchCenter for Cancer Research Informatics Core, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer ResearchBasic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer ResearchDepartment of Epidemiology, the Johns Hopkins Bloomberg School of Public HealthDepartment of Epidemiology, the Johns Hopkins Bloomberg School of Public HealthKidney Health Research Collaborative, Department of Medicine, University of California San FranciscoKidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, NIHBasic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer ResearchAn et al. determine the presence of variants of the innate immune factor APOL1 in four cohorts of HIV-positive patients. The study suggests that APOL1 might confer carriers of two variant alleles protection from HIV related opportunistic infections, especially fungal infections.https://doi.org/10.1038/s42003-021-01812-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ping An Efe Sezgin Gregory D. Kirk Priya Duggal Elizabeth Binns-Roemer George Nelson Sophie Limou Mark L. Van Natta Douglas A. Jabs Michelle Estrella Jeffrey B. Kopp Cheryl A. Winkler |
| spellingShingle |
Ping An Efe Sezgin Gregory D. Kirk Priya Duggal Elizabeth Binns-Roemer George Nelson Sophie Limou Mark L. Van Natta Douglas A. Jabs Michelle Estrella Jeffrey B. Kopp Cheryl A. Winkler APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection Communications Biology |
| author_facet |
Ping An Efe Sezgin Gregory D. Kirk Priya Duggal Elizabeth Binns-Roemer George Nelson Sophie Limou Mark L. Van Natta Douglas A. Jabs Michelle Estrella Jeffrey B. Kopp Cheryl A. Winkler |
| author_sort |
Ping An |
| title |
APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection |
| title_short |
APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection |
| title_full |
APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection |
| title_fullStr |
APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection |
| title_full_unstemmed |
APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection |
| title_sort |
apol1 variant alleles associate with reduced risk for opportunistic infections in hiv infection |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-03-01 |
| description |
An et al. determine the presence of variants of the innate immune factor APOL1 in four cohorts of HIV-positive patients. The study suggests that APOL1 might confer carriers of two variant alleles protection from HIV related opportunistic infections, especially fungal infections. |
| url |
https://doi.org/10.1038/s42003-021-01812-z |
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