The Philadelphia chromosome in leukemogenesis
Abstract The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2016-05-01
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Series: | Chinese Journal of Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40880-016-0108-0 |