The Philadelphia chromosome in leukemogenesis

Abstract The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic...

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Bibliographic Details
Main Authors: Zhi-Jie Kang, Yu-Fei Liu, Ling-Zhi Xu, Zi-Jie Long, Dan Huang, Ya Yang, Bing Liu, Jiu-Xing Feng, Yu-Jia Pan, Jin-Song Yan, Quentin Liu
Format: Article
Language:English
Published: BMC 2016-05-01
Series:Chinese Journal of Cancer
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40880-016-0108-0