Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2.

Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2.

Anti-angiogenic treatment of glioblastoma with Vascular Endothelial Growth Factor (VEGF)- or VEGF Receptor 2 (VEGFR2) inhibitors normalizes tumor vessels, resulting in a profound radiologic response and improved quality of life. This approach however does not halt tumor progression by diffuse infilt...

Full description

Bibliographic Details
Main Authors: Anna C Navis, Annika Bourgonje, Pieter Wesseling, Alan Wright, Wiljan Hendriks, Kiek Verrijp, Jeroen A W M van der Laak, Arend Heerschap, William P J Leenders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3587584?pdf=render

Internet

http://europepmc.org/articles/PMC3587584?pdf=render

Similar Items