RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo.

RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo.

Respiratory syncytial virus (RSV) infection can result in severe disease partially due to its ability to interfere with the initiation of Th1 responses targeting the production of type I interferons (IFN) and promoting a Th2 immune environment. Epigenetic modulation of gene transcription has been sh...

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Bibliographic Details
Main Authors: Catherine Ptaschinski, Sumanta Mukherjee, Martin L Moore, Mareike Albert, Kristian Helin, Steven L Kunkel, Nicholas W Lukacs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004978

Internet

https://doi.org/10.1371/journal.ppat.1004978

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