Rapid Evolution of HERC6 and Duplication of a Chimeric HERC5/6 Gene in Rodents and Bats Suggest an Overlooked Role of HERCs in Mammalian Immunity

Rapid Evolution of HERC6 and Duplication of a Chimeric HERC5/6 Gene in Rodents and Bats Suggest an Overlooked Role of HERCs in Mammalian Immunity

Studying the evolutionary diversification of mammalian antiviral defenses is of main importance to better understand our innate immune repertoire. The small HERC proteins are part of a multigene family, including HERC5 and HERC6, which have probably diversified through complex evolutionary history i...

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Bibliographic Details
Main Authors: Stéphanie Jacquet, Dominique Pontier, Lucie Etienne
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
HERC
restriction factor
antiviral immunity
gene duplication
genetic conflicts
positive selection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.605270/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.605270/full

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