16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

Microdeletions and microduplications of the 16p11.2 chromosomal locus are associated with syndromic neurodevelopmental disorders and reciprocal physiological conditions such as macro/microcephaly and high/low body mass index. To facilitate cellular and molecular investigations into these phenotypes,...

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Bibliographic Details
Main Authors: Julien G Roth, Kristin L Muench, Aditya Asokan, Victoria M Mallett, Hui Gai, Yogendra Verma, Stephen Weber, Carol Charlton, Jonas L Fowler, Kyle M Loh, Ricardo E Dolmetsch, Theo D Palmer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
iPSC
corticogenesis
neurodevelopment
16p11.2
copy number variation
Online Access:https://elifesciences.org/articles/58178

Internet

https://elifesciences.org/articles/58178

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