Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas

Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas

Abstract Pediatric high-grade gliomas (pHGGs) are aggressive neoplasms representing approximately 20% of brain tumors in children. Current therapies offer limited disease control, and patients have a poor prognosis. Empiric use of targeted therapy, especially at progression, is increasingly practice...

Full description

Bibliographic Details
Main Authors: Ralph Salloum, Melissa K. McConechy, Leonie G. Mikael, Christine Fuller, Rachid Drissi, Mariko DeWire, Hamid Nikbakht, Nicolas De Jay, Xiaodan Yang, Daniel Boue, Lionel M. L. Chow, Jonathan L. Finlay, Tenzin Gayden, Jason Karamchandani, Trent R. Hummel, Randal Olshefski, Diana S. Osorio, Charles Stevenson, Claudia L. Kleinman, Jacek Majewski, Maryam Fouladi, Nada Jabado
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Acta Neuropathologica Communications
Subjects:
Pediatric high-grade gliomas
Recurrence
Genomics
Histone 3
ATRX
IDH1
Online Access:http://link.springer.com/article/10.1186/s40478-017-0479-8

Internet

http://link.springer.com/article/10.1186/s40478-017-0479-8

Similar Items