Thrombin contributes to the injury development and neurological deficit after acute subdural hemorrhage in rats only in collaboration with additional blood-derived factors

Thrombin contributes to the injury development and neurological deficit after acute subdural hemorrhage in rats only in collaboration with additional blood-derived factors

Abstract Background Acute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated intracranial pressure. Thrombin is one of the potential harmful blood comp...

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Bibliographic Details
Main Authors: Tobias J. Krämer, Wasim Sakas, Daniel Jussen, Harald Krenzlin, Oliver Kempski, Beat Alessandri
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Neuroscience
Subjects:
Acute subdural hemorrhage
Thrombin
Neurotoxicity
Argatroban
PAR1
SCH79797
Online Access:http://link.springer.com/article/10.1186/s12868-018-0481-5

Internet

http://link.springer.com/article/10.1186/s12868-018-0481-5

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