Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms

Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms

Abstract Background After the golden age of antibiotic discovery, bacterial infections still represent a major challenge for public health worldwide. The biofilm mode of growth is mostly responsible for chronic infections that current therapeutics fail to cure and it is well-established that novel s...

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Bibliographic Details
Main Authors: David Da Costa, Chloé Exbrayat-Héritier, Basile Rambaud, Simon Megy, Raphaël Terreux, Bernard Verrier, Charlotte Primard
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Nanobiotechnology
Subjects:
Biofilm
PLA nanoparticles
Antibiotic
Delivery
Surface charge
Interaction
Online Access:https://doi.org/10.1186/s12951-020-00760-w

Internet

https://doi.org/10.1186/s12951-020-00760-w

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