TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles

TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles

Abstract Background The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in...

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Bibliographic Details
Main Authors: Nina Strah, Giulia Romano, Clelia Introna, Raffaella Klima, Marta Marzullo, Laura Ciapponi, Aram Megighian, Monica Nizzardo, Fabian Feiguin
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Biology
Subjects:
TDP-43
Skeletal muscles
Dlg
Neuromuscular junctions
ALS
Online Access:http://link.springer.com/article/10.1186/s12915-020-00767-7

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http://link.springer.com/article/10.1186/s12915-020-00767-7

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