Explicit representation of protein activity states significantly improves causal discovery of protein phosphorylation networks

Explicit representation of protein activity states significantly improves causal discovery of protein phosphorylation networks

Abstract Background Protein phosphorylation networks play an important role in cell signaling. In these networks, phosphorylation of a protein kinase usually leads to its activation, which in turn will phosphorylate its downstream target proteins. A phosphorylation network is essentially a causal ne...

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Bibliographic Details
Main Authors: Jinling Liu, Xiaojun Ma, Gregory F. Cooper, Xinghua Lu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Bioinformatics
Subjects:
Causal inference
Protein kinase activity state
Protein phosphorylation networks
Cancer signaling pathways
Online Access:http://link.springer.com/article/10.1186/s12859-020-03676-2

Internet

http://link.springer.com/article/10.1186/s12859-020-03676-2

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