Connexin 43 enhances Bax activation via JNK activation in sunitinib-induced apoptosis in mesothelioma cells

The constituent protein of gap junctions, connexin (Cx), interacts with various proteins via its C-terminus region, including kinases, cell-adhesion proteins, and a pro-apoptotic protein, Bax. This molecular interaction may affect expression and functioning of the interacting proteins and modulate t...

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Bibliographic Details
Main Authors: Miaki Uzu, Hiromi Sato, Ayaka Shimizu, Yukihiro Shibata, Koichi Ueno, Akihiro Hisaka
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Pharmacological Sciences
Subjects:
Bax
JNK
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317300798