Targeted blockade of TGF-β and IL-6/JAK2/STAT3 pathways inhibits lung cancer growth promoted by bone marrow-derived myofibroblasts

Targeted blockade of TGF-β and IL-6/JAK2/STAT3 pathways inhibits lung cancer growth promoted by bone marrow-derived myofibroblasts

Abstract To investigate the role of TGF-β and IL-6 in myofibroblasts (MFs) — lung cancer cell interactions, lung cancer cells (Lewis and CTM-167 cell lines) were stimulated by IL-6, MF-conditioned medium (MF-CM) or MFs, with or without TGF-β signaling inhibitor — SB431542 and/or JAK2/STAT3 inhibitor...

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Bibliographic Details
Main Authors: Jindong Shi, Jingjing Feng, Juan Xie, Zhoufang Mei, Tianyun Shi, Shengmei Wang, Yong Du, Gong Yang, Yougen Wu, Xiaojiao Cheng, Shanqun Li, Liming Zhu, Chung S. Yang, Shuiping Tu, Zhijun Jie
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09020-8

Internet

https://doi.org/10.1038/s41598-017-09020-8

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