Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

Sammy Alhassen, Siwei Chen, et al. use mouse models to examine the effects of prenatal and postnatal stress on metabolomic and transcriptomic pathways in the brain. Their results suggest that altered mitochondrial metabolism may underlie trauma-induced behavioral deficits, and that correcting metabo...

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Bibliographic Details
Main Authors: Sammy Alhassen, Siwei Chen, Lamees Alhassen, Alvin Phan, Mohammad Khoudari, Angele De Silva, Huda Barhoosh, Zitong Wang, Chelsea Parrocha, Emily Shapiro, Charity Henrich, Zicheng Wang, Leon Mutesa, Pierre Baldi, Geoffrey W. Abbott, Amal Alachkar
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02255-2

Internet

https://doi.org/10.1038/s42003-021-02255-2

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