MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication.

MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication.

Successful replication and transmission of large DNA viruses such as the cytomegaloviruses (CMV) family of viruses depends on the ability to interfere with multiple aspects of the host immune response. Apoptosis functions as a host innate defence mechanism against viral infection, and the capacity t...

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Bibliographic Details
Main Authors: Peter Fleming, Marc Kvansakul, Valentina Voigt, Benjamin T Kile, Ruth M Kluck, David C S Huang, Mariapia A Degli-Esposti, Christopher E Andoniou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-02-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23468630/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23468630/?tool=EBI

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