Beyond <i>LKB1</i> Mutations in Non-Small Cell Lung Cancer: Defining LKB1less Phenotype to Optimize Patient Selection and Treatment

Beyond <i>LKB1</i> Mutations in Non-Small Cell Lung Cancer: Defining LKB1less Phenotype to Optimize Patient Selection and Treatment

LKB1 is frequently mutated in non-small cell lung cancer (NSCLC). LKB1-mutated NSCLCs often have a dismal prognosis and receive lower benefit from the currently available therapies. LKB1 acts as a cell emergency brake in low-energy conditions, by modulating the activity of crucial anabolic enzymes....

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Bibliographic Details
Main Authors: Cristina Borzi, Giulia Galli, Monica Ganzinelli, Diego Signorelli, Claudio Vernieri, Marina Chiara Garassino, Gabriella Sozzi, Massimo Moro
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceuticals
Subjects:
NSCLC
LKB1
LKB1less phenotype
metformin
epigenetic regulation
Online Access:https://www.mdpi.com/1424-8247/13/11/385

Internet

https://www.mdpi.com/1424-8247/13/11/385

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