Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation

<p>Abstract</p> <p>Background</p> <p>Many studies implicate Arf6 activity in Rac-mediated membrane ruffling and cytoskeletal reorganization. Although Arf6 facilitates the trafficking of Rac1 to the plasma membrane and in many cases Arf6 activation leads to the activatio...

Full description

Bibliographic Details
Main Authors: Donaldson Julie G, Eipper Betty A, Koo Tae
Format: Article
Language:English
Published: BMC 2007-07-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/8/29