Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma

Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma

Abstract Background Optimizing the therapeutic ratio for radiation therapy (RT) in head and neck squamous cell carcinoma (HNSCC) is uniquely challenging owing to high rates of early and late toxicity involving nearby organs at risk. These toxicities have a profound impact on treatment compliance and...

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Bibliographic Details
Main Authors: Whitney Sumner, Xenia Ray, Leisa Sutton, Daniel Rebibo, Francesco Marincola, Parag Sanghvi, Vitali Moiseenko, Ida Deichaite
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Translational Medicine
Subjects:
Predictive biomarkers of radiation toxicity
Head and neck squamous cell carcinoma
Radiogenomics
BRCA2
ERBB3
RT dosimetric data
Online Access:https://doi.org/10.1186/s12967-021-02876-5

Internet

https://doi.org/10.1186/s12967-021-02876-5

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